Critical appraisal of a systemic review and Meta- analysis

Citation: Kochan, J. A., Desclos, E. C., Bosch, R., Meister, L., Vriend, L. E., Attikum, H. V., & Krawczyk, P. M. (2018). Quality of life in people with vitiligo: a systematic review and meta-analysis. British Journal of Dermatology177(6), 12625–12637.



Are the results of this systematic review valid?
1. Was the review question clearly and explicitly stated? Was it a focused review question?


2. What was the review question?  



3. Did the systematic review include a methods section that described:  
a) a comprehensive, exhaustive search strategy for finding and including all the relevant studies? What databases and sources were searched? Was the search adequate? Were non-English studies excluded?  
b) the criteria used to decide which studies to include in the review (i.e. were the inclusion criteria reported and justified?) Was study selection reproducibly done (i.e. by two independent reviewers)? Was bias in selection of studies avoided?  
c) how the reviewers assessed the validity (i.e. quality) of each study included in the review? Was study quality assessment reproducibly done (i.e. by two independent reviewers)? Were all the included studies of high methodologic quality?  
4. If meta-analysis was done, how were the study results combined (pooled)? Were the meta-analysis methods appropriate? What statistical model was used for meta-analysis?


5. Did the reviewers check for heterogeneity? What method was used?


6. Did the reviewers check for publication bias? What method was used? Is it likely that relevant studies were missed?


7. Did the reviewers assess the potential impact of study quality on the results of the SR?  


Any other potential biases or flaws in this systematic review?


What are the results?


What are the results of the systematic review?


1. Were the results similar from study to study, both clinically and statistically?


ü  Were the populations of the different studies similar?

ü  Was the same exposure/intervention evaluated by the individual studies?

ü  Was the same outcome evaluated by the individual studies?

ü  If heterogeneity was found, did the reviewers seek to explore reasons for heterogeneity?

ü  What methods (e.g. subgroup analysis or meta-regression) were used to ascertain reasons for heterogeneity?



2. What are the overall results of the review?  








3. How precise were the results?  








4. Were conclusions made by the review authors supported by the data presented in the review?






In summary:


What are the major strengths of this systematic review?


What are the major limitations of this systematic review?


Based on your assessment of this systematic review, would you accept the conclusions of the review?



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