I am going to present the first drug that hit 1 billion Doller. Diazepam, also is known by the brand name valium.
Diazepam is the number 1 prescription drug in 1975 and the sales peaked with more 2.3 million of pills sold that year in US.
Between 1968 and 1982, Diazepam had been prescribed to 59.3 million patients
In In 1985, Diazepam patent was expired which facilitied to other pharmaceutical companies to manufacture the drug on generic basis
Since then the diazepam prescriptions were down according to IMS Health,
The graph illustrates the number of diazepam’s prescription from 2007 to 2017
In 2017, there were more than five million prescriptions.
How diazepam works
Diazepam promotes the profound action of gamma-aminobutyric acid (GABA), which produce calming effects that help reduce anxiety, relax the muscles, or stop seizures.
(GABA) is defined as an inhibitory neurotransmitter in the brain that blocks abnormal signals and decreases its activity in the nervous system.
Diazepam is bind to the Y subunite on GABA A receptor which result in opening GABA A receptor that leading to chlorides ion to inflex into neuron.
Diazepam increases the frequence of opening the GABA A receptor which can increase conductance of chloride ions. Consequensly, it leads to a hyperpolarization of the neuronal membrane and reduced excitability of the neuron.
Rout of administration
Diazepam is available in multiple formulations, including oral tablets, intramuscular injections (IM), intravenous injection (IV), or rectal gel
Diazepam is highly lipid soluble and it is bound to plasma proteins at a high level of 98%, which allow its distribution through tissue and across the blood-brain barriers.
Diazepam is metabolized in liver to either nordiazepam by CYP 2C19 or temazepam by CYP3A4. Nordiazepam and temazepam are hydroxylated and demethylated to oxazepam. Oxazepam is then glucuronidated and excreted in the urine.
in cases of severe overdose, symptoms manifest as cardio-respiratory depression, and coma.
Also, the combination of diazepam with alcohol and opioids can lead to fatal events.
We value our customers and so we ensure that what we do is 100% original..
At Custom Writing, we believe in exemplary services that are fully geared toward customer satisfaction. That is why we don’t shy away from giving you the following guarantees;
Trusting us with your work is the best decision you have made, our pleasure lies in seeing you satisfied at 100%. If in the rear chance it happens that you are not satisfied, then know that we will equally not be satisfied. But worry not, our 30 days- Money back guarantee is all you need and that is what we promise you..Read more
We utilize profoundly equipped and gifted writers who produce unique papers liberated from any form of plagiarism. To guarantee this, we run all papers finished by our scholars through a Plagiarism checker to ensure uniqueness and originality. In any case, on the off chance that you have vulnerabilities about the originality or falsification of any paper we have finished and conveyed to you, please get in touch with us straight away. We will quickly investigate, and if the paper is seen as counterfeited, we will take suitable actions including but not limited to, revising the paper for free and in extreme cases we will activate the money back guarantee.Read more
We have an obligation deliver great and specially composed assignments. Our revision strategy endeavors to ensure total client satisfaction, comfort, and a genuine feelings of serenity. We make minor updates and corrections to the underlying request as part of our continuous assistance. However, revisions should just incorporate changes and alterations that were not effectively met, in the underlying request and that are inside the rules as per the current request structure..Read more
Our client's Data is an Integral part of our business but clearly, we are not in the business of offering our clients' very own data to others. We realize that you care how your online data is utilized and shared, we equally value your trust that we will do so cautiously and sensibly. We Promise to ensure the security of your own data during transmission by utilizing encryption conventions and programming. Likewise assist us with securing your information by not sharing your passwords and usernames.Read more
In submitting a request with us, you consent to the services we give. We will strive to take the necessary steps to convey a far reaching paper according to your prerequisites. Equally we depend on your cooperation to guarantee that we convey on this order.Read more